Immunological Unresponsiveness to Sensitization with Simple Chemical Compounds

The factors influencing the immune response to hepatitis B vaccine and persistence of the protection.

 Hepatitis B virus (HBV) infection and its sequelae which include cirrhosis and hepatocellular carcinoma is a major public health problem throught the world.The WHO strategy for effective control of HBV infection is vaccination with the surface antigen of virus(HBsAg).The results obtained from a large number of studies demonstrated that the vaccine induces a protective antibody resonse (anti-HB...

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS VIII. SENSITIZATION TO PICRIC Acre; SvBsn)I~mY AGENTS AND MODE OF SENSITIZATION BY K. LANDSTEINER, M.D., AND A. A. DI SOMMA, PH.D

Studies on the Sensitization of Animals with Simple Chemical Compounds Ix. Skin Sensitization Induced by Injection of Conjugates

In experimental work on sensitization with a group of simple chemical substances, strong evidence was obtained for the view that the production of hypersensitivity depended upon the formation of antigenic combinations in the body (1). As a corollary, the direct administration of in vitro conjugates in these cases should lead to skin sensitivity towards the corresponding low molecular substance....

Inheritance in Guinea Pigs of the Susceptibility to Skin Sensitization with Simple Chemical Compounds

It has proved possible to set up lines of guinea pigs of significantly different susceptibilities towards a compound of simple structure, namely 2:4 dinitrochlorobenzene. This provides direct evidence that the type of sensitization under discussion is influenced by heredity.

Fetal growth modified by natural and induced changes in maternal reactivity.

Maternal immunological unresponsiveness has usually been demonstrated with adult tissue allografts. Experiments were first directed to the question of whether maternal reactivity to allogeneic conceptuses parallels that of implants of allogeneic tumor. BALB/c female mice parous by C3H males for one to eight litters and challenged with Tumor 70429 of C3h origin showed increasing unresponsiveness...